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@NILS nails this.
Conventions are there for a reason and for 90% of the work you’ll do it would be counter productive to remove, contradict or otherwise ignore these conventions.
Users who aren’t visiting the website to be astonished by your web 3.0 sideways flying menu with upside-down text will just get lost, get confused and get the hell off the website.
Sure, if you’re building a site for the sole purpose of showing off your skills and the audience will ‘get’ the unconventional, go for it… but I think in the real world these kinds of projects are few and far between.